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Drake received both his bachelor’s degree in electrical engineering and his master’s degree in biomedical engineering from Rutgers University. As co-director of the Prostate Cancer Multi-Disciplinary Clinic, he developed a novel transgenic model of prostate cancer, in which a unique antigen is expressed exclusively in the prostate gland and in prostate tumors.ĭr. He is also a professor of oncology, urology, and immunology. Drake served as the co-director of the Cancer Immunology Program at Johns Hopkins Kimmel Cancer Center. Prior to joining NewYork-Presbyterian/Columbia, Dr.
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His research has been published in prestigious journals such as the New England Journal of Medicine, Cancer Research, the Journal of Clinical Investigation, and the Journal of Clinical Oncology. His most recent work has focused on the body’s immunological response to radiation therapy and how immunotherapy and radiation therapy can be used in concert to treat cancer. These discoveries were then translated into clinical trials. Further work demonstrated that LAG-3 and PD-1 were co-expressed on functionally exhausted CD8 T cells, suggesting that blockade of multiple immune checkpoints might be required to restore anti-tumor immunity. The Drake laboratory was the first group to show that LymphocyteActivation Gene–3 (LAG-3) is a cell surface marker for CD4 cells with regulatory function (Treg) and that blockade of LAG-3 with a monoclonal antibody could restore anti-tumor immune responses by mitigating CD8 T-cell tolerance in vivo. He is known for rapidly incorporating discoveries made in the research lab into innovative clinical trials, including anti-tumor vaccines. in immunology, whose work focuses on understanding and fighting advanced-stage cancers with the immune system. Drake is a physician-scientist with a Ph.D.